STEM CELL CLINICAL TRIALS
Stem cell research is one of the fastest-growing branches of medical technology. Scientists from around the world are performing clinical trials to explore the use of both cord blood and cord tissue stem cells to treat diseases such as osteoporosis, Alzheimer’s, diabetes, heart disease, liver failure and arthritis. Here we highlight some of the current clinical trials involving newborn stem cells. Additional information on clinical trials examining the therapeutic potential of stem cells can be found at ClinicalTrials.gov.
Heart Disease
Heart disease is one of the leading causes of death in both men and women. Approximately 17 million people die from cardiovascular disease every year accounting for 31% of deaths worldwide.
The heart (cardiac) muscle has limited regenerative capabilities. This is why many patients who have a heart attack go on to develop progressive heart failure over-time. Researchers in regenerative medicine are exploring the option of repairing damaged heart muscle using stem cells from a variety of sources. Below are some of the latest clinical trials exploring the use of newborn stem cells:
CLINICAL TRIAL ID: NCT04056819
Evaluating the safety and effectiveness of using umbilical cord mesenchymal stem cells in acute myocardial infarction
CLINICAL TRIAL ID: NCT04340609
Stem cell in acute myocardial infarction (AMI)
CLINICAL TRIAL ID: NCT04325594
The application of the umbilical cord mesenchymal stem cells in the complex treatment of chronic heart failure of non-ischemic etiology (RegenHeart)
CLINICAL TRIAL ID: NCT03902067
UC-MSC transplantation for left ventricular dysfunction after AMI
Type 2 Diabetes
Type 2 diabetes is a highly prevalent condition that is difficult to treat. It is estimated that this disease will affect as many as 1 in 10 people by the year 2030.
People with type 2 diabetes are unable to regulate the sugar levels in their blood, either because their cells no longer respond to the hormone insulin or because beta cells in the pancreas do not produce sufficient levels of insulin. Researchers are looking at ways to restore beta cell function as a new treatment option for type 2 diabetes.
CLINICAL TRIAL ID: NCT04441658
Efficacy and safety of umbilical cord mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus
CLINICAL TRIAL ID: NCT04216849
Clinical study of umbilical cord mesenchymal stem cells in the treatment of type 2 diabetic nephropathy
CLINICAL TRIAL ID: NCT03943940
Bone marrow mononuclear cells (BM-MNCs) and umbilical cord tissue-derived mesenchymal stem cells (UC-MSCs) infusion for type 2 diabetes mellitus patients (T2DM)
COVID-19
[ 57 active clinical trials exploring COVID-19 | as of July 14, 2020 ]
More than 13 million people worldwide have been infected by COVID-19. Researchers around the world are struggling for ways to treat and prevent the spread of COVID-19 as it is imperative for emerging out of this pandemic. Below are some clinical trials looking at the use of umbilical cord stem cells to tackle COVID-19.
CLINICAL TRIAL ID: NCT04273646
Study of human umbilical cord mesenchymal stem cells in the treatment of severe COVID-19.
CLINICAL TRIAL ID: NCT04269525
Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) treatment for the 2019-novel coronavirus (nCOV) pneumonia
CLINICAL TRIAL ID: NCT04355728
Use of human umbilical cord derived mesenchymal stem cells (UC-MSCs) for COVID-19 patients
CLINICAL TRIAL ID: NCT04288102
Treatment with human umbilical cord-derived mesenchymal stem cells for severe corona virus disease 2019 (COVID-19)
CLINICAL TRIAL ID: NCT04461925
Treatment of coronavirus COVID-19 pneumonia (pathogen SARS-CoV-2) with cryopreserved allogeneic placenta-derived multipotent mesenchymal stroll cells (P-MMSCs) and umbilical cord-derived multipotent mesenchymal stroll cells (UC-MMSCs)
Osteoarthritis
Osteoarthritis is the most common form of arthritis caused by the wearing off of the cartilage between bones. It affects more than a million people worldwide, often leading to severe disability. Preliminary studies and clinical trials suggest mesenchymal stem cells may offer pain relief to osteoarthritis suffers.
CLINICAL TRIAL ID: NCT03800810
Implantation of allogenic mesenchymal stem cell From umbilical cord blood for osteoarthritis management
CLINICAL TRIAL ID: NCT03166865
Clinical study of umbilical cord mesenchymal stem cells (UC-MSC) for treatment of knee osteoarthritis
CLINICAL TRIAL ID: NCT03818737
Multicenter trial of stem cell therapy for osteoarthritis (MILES)
CLINICAL TRIAL ID: NCT03358654
Evaluating safety and efficacy of mesenchymal stem cells from umbilical cord
CLINICAL TRIAL ID: NCT03383081
The safety/efficacy of human umbilical cord mesenchymal stem cells (19#iSCLife®-OA) therapy for patients with osteoarthritis
CLINICAL TRIAL ID: NCT04234412
Treatment of osteoarthritic knee with high tibial osteotomy and implantation of allogenic human umbilical cord blood-derived stem cells
Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is a serious lung condition that is caused by underdeveloped lungs. There are abnormal changes in the structure or the organization of cells in the smaller airways and the air sacs (alveoli) of the lung that makes breathing difficult and affects lung function. BPD mostly affects newborn babies, particularly those who are born prematurely.
CLINICAL TRIAL ID: NCT03645525
Intratracheal umbilical cord-derived mesenchymal stem cell for the treatment of bronchopulmonary dysplasia (BPD) (IUMTB)
CLINICAL TRIAL ID: NCT04062136
Umbilical cord mesenchymal stem cells transplantation in the treatment of bronchopulmonary dysplasia
CLINICAL TRIAL ID: NCT03601416
CLINICAL TRIAL ID: NCT03558334
Additional Clinical Trials
We have highlighted in this page the latest clinical trials exploring umbilical cord stem cells as a therapeutic option for a number of diseases. Researchers are also investigating the potential of using stem cells to treat and manage numerous other conditions including autism spectrum disorder, cancers, cerebral palsy, Alzheimer’s disease, Parkinson’s disease, liver disease and kidney disease to list a few.
More information on additional clinical trials involving stem cells can be found at ClinicalTrials.gov.